Description

About the Company

Marea Therapeutics is a clinical-stage biotechnology company based in San Francisco with a growing pipeline of first-in-class therapies to address genetically validated cardioendocrine disease targets. Our therapies have the potential to complement existing therapies and serve as transformative treatment options for significant patient populations living with cardioendocrine diseases.

Incubated by Third Rock Ventures, Marea completed a Series B financing in June 2024 and is now well funded by a syndicate of life science investors including Sofinnova, Forbion, Perceptive Advisors, Xontogeny, venBio, Omega Funds, Surveyor, Alpha Wave and Third Rock Ventures. The company’s lead program is in Phase 2 clinical development (MAR001) and a second program is progressing towards clinical development acromegaly. Marea is a fast-growing company looking for extraordinary individuals to join our team who want to make a difference in the lives of millions of people living with cardioendocrine diseases. The company is led by a dynamic team of scientists and company builders with deep knowledge and experience in cardioendocrine diseases, human genetics, and adipocyte biology.

At Marea, we believe in the power of collaboration and the importance of leading by example. We are a tight-knit team that values the contributions of every member, from interns to senior leaders. Our environment is dynamic, with each day presenting new challenges and opportunities for growth. Every role is “Hands-On”, and the successful candidate will be able to work alongside team members, regardless of level, to understand challenges and drive results.

About The Role

We are looking for a Senior Director of Biostatistics to join our team in a critical leadership position responsible for overseeing and directing all aspects of statistical analysis related to the company’s clinical trials and other research activities. They will help guide the design, execution, and interpretation of preclinical and clinical studies to ensure that the results are statistically aligned with corporate and regulatory requirements.

This is a FTE position with a preference for candidates that can regularly work in the San Francisco-based office.

Job Responsibilities

• Statistical planning for, and interpretation of, preclinical and clinical programs
• Work cross-functionally to find strategic and creative problem-solving for statistical approaches in studies, including researching new statistical methods to support program needs that align with regulatory and industry standards
• Ensure the statistical strategy aligns with the company’s business objectives which includes understanding the company’s goals when it comes to the regulatory submissions, scientific publications, and other corporate needs
• Collaborate with thought leaders and experts in the field to ensure that statistical methods and findings are in line with best practices and the latest scientific and statistical advancements
• Define, institute, and oversee best practices with regard to planning, execution, handling, and interpretation of scientific and clinical results to ensure high quality and compliant data handling and interpretation
• Ensure strong data handling and infrastructure, including ongoing evaluation and implementation of systems and vendors
• Identify, engage, and manage key biometrics vendors, consultants, and thought leaders (e.g., in statistics, programming, and data management)
• Provide statistical oversight and support global regulatory strategy, planning, submissions, and interactions
• Anticipate, identify, and assist in the resolution of risks, bottlenecks, and potential issues in biometrics-related activities
• Continually assess and plan for appropriate resourcing to meet approved biometrics initiatives
• Provide regular updates to cross-functional and leadership teams to ensure alignment, resourcing, and tracking
  
  

Requirements

Qualifications

• PhD in statistics or related field
• At least 10 years in related positions in pharmaceuticals/biotechnology, with increasing responsibility and which must include planning, analysis, and reporting of clinical trials
• Experience in cardiovascular, metabolic diseases, and/or rare diseases is a plus
• Proven leadership of teams and vendors including statisticians, programmers, and data managers
• In-depth knowledge of all phases of the global drug development
• Experience in supporting large, long-term studies and clinical development plans is a plus
• Demonstrated ability to work in a cross-functional environment
• Knowledge of global regulatory submission processes and able to provide support to the regulatory team
• Experience with supporting publications and communications strategies
• Strong verbal and written communication, presentation, and interpersonal skills to be effective in communicating and interacting with a diverse group of people
• Superb attention to detail
• Exceptional time and project management skills, with the ability to execute on plans under pressure in a small, fast-paced environment with tight deadlines
• High integrity and sense of urgency, with a desire to individually contribute and lead
• Highly motivated, proactive, enthusiastic and goal orientated
• The ability to anticipate potential pitfalls, and proactively solve problems
• The ability to work independently as well as coordinate and work with large cross-functional teams
  
  

Working Conditions

• Prolonged periods of being at a stationary desk or work computer
• Ability to occasionally adjust, handle, or move objects up to [50] pounds
• Assessing the accuracy, neatness, and/or thoroughness of the work assigned
• Communicating with others to exchange information
• Travel requirements as needed
  
  

Further information

Annual Salary Range: $$215,000-$285,000

The salary range listed here has been provided to comply with local regulations and represents a potential base salary range for this role. Please note that actual salaries may vary within the range above or below, depending on experience and location. We look at compensation for each individual and base our offer on your unique qualifications, experience, and expected contributions. This position may also be eligible for other types of compensation in addition to base salary.

In addition to a competitive compensation package, Marea also offers a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, health spending account, life insurance, disability insurance, time off and a 401(k) plan.

We do not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity or expression, national origin, age, disability, veteran status, marital status, or based on an individual’s status in any group or class protected by applicable federal, state, and local law.