We are searching for a Lead Antibody Production Manager to join one of our large pharmaceutical clients in Spring House, PA as a direct full-time employee on the Expression Sciences team within the R&D Therapeutics Discovery organization. While this Manager will directly supervise a team of Scientists, they will also be hands-on in the lab and should be a passionate scientist with expertise in protein expression, molecular biology and biochemistry. The successful candidate is an empathetic leader who recognizes the contributions of others and brings out the best in people. This department is a central piece to the company’s discovery engine, generating therapeutic candidates, including ground-breaking Multispecific antibodies and antibody drug conjugates. They strive to capitalize on their talents to discover next-generation medicines to help patients in need. This Manager will lead a team of Scientists to express complicated proteins, engineer mammalian cells, innovate upstream processes, and deliver creative research solutions to formidable drug discovery challenges. Primary responsibilities include:

• Lead and mentor a team of Scientists that express candidate biotherapeutic molecules in stable mammalian cell culture systems.
• As a protein expression expert, interpret complex datasets to identify and mitigate risks as part of the discovery process. Creatively identify drug developability trends by modeling large datasets.
• Identify value-adding innovative protein production capabilities, industry trends, and emerging technologies and work to evaluate these. Lead creative research efforts (e.g. using ‘omics and screens) to push efficiencies and maintain organizational competitiveness.
• Collaborate across the company’s global functions to discover innovative medicines. Communicate regularly and accurately within the department and with company leadership to drive decision making.
• Lead drug discovery projects and research initiatives, ensuring alignment with the company’s strategic goals.
• Prepare and present reports, proposals, and primary data to senior management and partners. Coordinate timelines and deliverables with a wide range of partners and stakeholders.
• Foster a culture of continuous improvement, innovation, learning and development.

Required Education/Experience:

• Minimum of Ph.D. in molecular biology, biochemistry, cell biology or similar field with a minimum of 4 years of industry experience
• Proven experience with people management
• Recombinant protein expression expertise, including hands-on experience with methods like mammalian cell culture (CHO & HEK293), transfection, and bioreactors.
• Expertise in molecular biology including cloning approaches, RNA seq, ATAC-seq, ChIP-seq, or CRISPR mutagenesis
• Excellent interpersonal skills, both written and verbal, with the ability to convey nuanced information clearly
• Proficiency with electronic notebooks (ELN), databases and laboratory information management systems (LIMS)

Preferred Experience:

• Practical experience purifying recombinant proteins using Akta systems with affinity chromatography, IEX, HIC, and MMC
• Experience with analytical methods such as HPLC, CE-SDS, SDS PAGE, BLI, and proteomic approaches
• Expertise with big data modeling and bioinformatics
• Experience working on multiplexed teams

Salary Range: $150,000-$160,000 + 15% Bonus

Hours: Monday-Friday, 8:00am-5:00pm

Hiring Method: Full-time, permanent opportunity

Benefits Include: Competitive Plans for Insurance, Retirement, PTO, Leave, Tuition Reimbursement, Commuter Benefits, Professional Development as well as Income Protection.

Exact compensation may vary based on several factors, including skills, experience, and education. Benefit packages for this role will start on the 31st day of employment and include medical, dental, and vision insurance, as well as HSA, FSA, and DCFSA account options, and 401k retirement account access with employer matching. Employees in this role are also entitled to paid sick leave and/or other paid time off as provided by applicable law.